Ryan, who was slated to start at inside linebacker, was carted off from practice with the injury. It is likely he will miss the 2018 season.
The injury occurred during an 11-on-11 drill late in Sunday’s practice. Ryan pounded his fist on the ground as he received medical attention.
The injury will accelerate the need for rookie third-round pick Oren Burks to play a bigger role on defense. Also, defensive back Quinten Rollins has worked at inside linebacker in the sub packages, and the Packers are high on undrafted rookie linebacker Greer Martini of Notre Dame.
ESPN’s Rob Demovsky contributed to this report.